Article provided by: bosterbio.com
The P53 antibody acts as a suppressor in many tumor types. Known as antigen NY-CO-13, LFS1, and transformation-related protein 53, this full-length protein targets P53. Bosterbio Antibody and ELISA experts supplies kits for humans, mice, and rats as well as vials for use with human tumor cells.
What is P53?
The P53 gene is a protein encoded by homologous genes in humans as well as other animals such as mice. While variants differ slightly, the homolog is vital in multicellular organisms.
Researchers refer to this gene as “the guardian of the genome” due to its ability to suppress tumor formation. Scientists discovered these properties in the 1970s.
How does P53 work?
The P53 protein regulates progression through the cell cycle. The protein can active DNA repair when damage is sustained.
Other features include the ability to initiate apoptosis as well as arresting growth by holding the cell cycle at the G1/S point, which helps in repair. The ability to limit growth is also a reason for use in studies involving creating a tumor suppressant.
Other roles of P53
While successful in helping with cellular repair and regulation, P53 also provides other useful functions. The ability to repair DNA means that the protein plays a role in aging.
Levels of P53 also play a vital role in the maintenance of stem cells throughout human lifespans. Embryonic stem cells maintain the protein at low inactive levels.
How is P53 activated?
The protein activates in response to stressors. This includes damage to DNA, oxidative stress, osmotic shock, and deregulated oncogene expression.
Activation is marked by two events. P53 accumulates dramatically before conformation change activates the regulation process. The critical event in the activation is the phosphorylation of the N-terminal domain.
Protein kinases known to target the transcriptional activation of P53 are included in two groups. The MAPK family and CHK1, CHK2, TP53RK, CAK, ATR, and ATM are also involved.
What diseases are related to P53?
The P53 protein is a tumor suppressor. Therefore, the antibody is related to cancer.
Studies attempting to link TP53 found that a mutation resulted in a profound impact on pancreatic cancer risk in males. Studies of Arab women also found a link between TP53 codon 72 and a decreased risk for breast cancer. While the results are controversial, they are promising.
How is the P53 antibody used?
A P53 antibody is a useful tool in studying the effects of the gene on tumors. Debates over the effectiveness of TP53 as a significant factor in the detection of various cancers continues.
Suppressing levels of active TP53 allows researchers to examine a link between the gene and cancer. The antibody successfully controls the presence of the gene.
Where can I find P53 antibodies?
Bosterbio Antibody and ELISA kits offers high-quality P53 antibodies in 100 microgram vials for human research as well as ELISA kits for mice, rats, and humans. Our polyclonal picoband antibody includes next day shipping. Visit our website to find out more about P53 antibody solutions.